Saturday, February 04, 2006

High folate intake may reduce risk of Alzheimer's disease

Study findings have suggested an association between Alzheimer's disease (AD) risk and several vitamins when used as preventive agents. In a recent study published in the journal Alzheimer's and Dementia, researchers examined whether total intake of antioxidant vitamins (E, C, carotenoids) and B vitamins (folate, B6, and B12) is associated with a reduced risk of AD.

Participants were 579 nondemented elderly volunteers from the Baltimore Longitudinal Study of Aging who completed dietary diaries and recorded supplement intake. After more than 9 nine years of follow-up, AD developed in 57 participants. Higher intake of folate, vitamin E, and vitamin B6 were associated individually with a decreased risk of AD after adjusting for age, gender, education, and caloric intake. When these 3 vitamins were analyzed together, only total intake of folate at or above the RDA was associated with a significant decreased risk of AD.

The findings of this study suggest that total intake of folate at or above the RDA may be associated with a reduced risk of Alzheimer's Disease.

Alzheimer's and Dementia 2005 Jul:1 (1):11-18.

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